Find out all about dreams and you will know all about insanity. —Hughlings Jackson.

Newborn screening (NBS) began in the 1960s by testing all newborns for a single condition—phenylketonuria, or PKU—which, when identified and treated early, significantly reduces morbidity. Over the...

Humans, animals, and the environment face a universal crisis: antimicrobial resistance. Addressing AR and its multi-disciplinary causes across many sectors including in human and veterinary medicine remains underdeveloped. One barrier to AR efforts is an inconsistent process to incorporate the plenitude of stakeholders about what AR is and how to stifle its development and spread—especially stakeholders from the animal agriculture sector, one of the largest purchasers of antimicrobial drugs. In 2019, The Wellcome Trust released Reframing Resistance: How to communicate about (...) antimicrobial resistance effectively, which proposed the need to establish a consistent and harmonized messaging effort that describes the AR crisis and its global implications for health and wellbeing across all stakeholders. Yet, Reframing Resistance does not specifically engage the animal agriculture community. This study investigates the gap between two principles recommended by Reframing Resistance and animal agriculture stakeholders. For this analysis, the research group conducted 31 semi-structured interviews with a diverse group of United States animal agriculture stakeholders. Participants reported attitudes, beliefs, and practices about a variety of issues, including how they defined AR and what entities the AR crisis impacts most. Exploration of Reframing Resistance’s Principle 2, “explain the fundamentals succinctly” and Principle 3, “emphasis that this is universal issue; it can affect anyone, including you” reveals disagreement in both the fundamentals of AR and consensus of “who” the AR crisis impacts. Principle 2 may do better to acknowledge that animal agriculture stakeholders espouse a complex array of perspectives that cannot be summed up in a single perspective or principle. As a primary tool to combat AR, behavior change must be accomplished first through outreach to stakeholder groups and understanding their perspectives. (shrink)

This article engages Kojonen's discussion of scientific explanation. Kojonen claims the best way to conceptualize the relationship between evolutionary explanations and explanation by design is through the proximate-ultimate distinction and the levels metaphor. However, these are not robust explanatory models but examples of how one might differentiate ambiguous explananda contained in why-questions. Disambiguating explananda is a helpful tool for determining when a situation calls for further explanation; however, on this picture, that some further explanation is needed does not, as proponents (...) of design arguments assume, specify design. The question of whether design is a good explanation at all hinges on what precisely we want explained. (shrink)

In Fortunes of History Donald R. Kelley offers an authoritative examination of historical writing during the "long nineteenth century"--the years from the French Revolution to those just after the First World War. He provides a comprehensive analysis of the theories and practices of British, French, German, Italian, and American schools of historical thought, their principal figures, and their distinctive methods and self-understandings. Kelley treats the modern traditions of European world and national historiography from the Enlightenment to the "new histories" of (...) the twentieth century, attending not only to major authors and schools but also to methods, scholarship, criticisms, controversies, ideological questions, and relations to other disciplines. (shrink)

Let me discuss first the principal points raised in the extensive commentaries from the three invited respondents. I shall next turn to the other shorter comments in the second part of this respons...

The Christian conviction about Divine Providence encourages a novel account of the moral content of health and authority in the heath care context. While health can be understood as the disposition of a living body to be able to proceed in the world well, as a species of freedom it is informed by the particular projects and concerns that Christians hold deepest. This is due to the fact that health acquires content, and thus becomes desirable as a particular type of (...) good, only in relation to judgments about the good life. Aquinas' reflections concerning the good of health and its partial slavery to fortune reveal a Christian past that dwelt on the intrinsic and instrumental good of health. A rich Christian tradition in which health as intrinsically good, a good of the body, is ordained to the interests of right Christian virtue. Each of these factors affects the character of the health to be pursued and the authority of the physician as determining the ends and means of medicine. (shrink)

The proposal that there is an illusion of conscious will has been supported by findings that priming of stimulus location in a task requiring judgements of action-authorship can enhance participants’ experience of agency. We attempted to replicate findings from the ‘Wheel of Fortune’ task [Aarts, H., Custers, R., & Wegner, D. M. . On the inference of personal authorship: enhancing experienced agency by priming effect information. Consciousness and Cognition, 14, 439–458]. We also examined participants’ performance on this task in (...) relation to self-reported passivity experiences and hallucination-proneness. We found a significant effect of priming, with primes being found to increase the experience of agency. An interaction between gender and priming was also found, with priming enhancing feelings of agency in women but not in men. There were no significant correlations between levels of self-reported passivity experiences or hallucination-proneness and participants’ susceptibility to the priming effect on ratings of agency. Implications of these findings are discussed with regard to a prominent model of passivity experiences. (shrink)

ABSTRACTThis article, which summarises some of the main arguments of Analogical Investigations [Lloyd 2015], undertakes a comparative cross-cultural critique of the dominant Western view that downgrades analogy especially when that is contrasted unfavourably with a notion of axiomatic-deductive demonstration aiming to secure incontrovertible conclusions. It draws on materials from ancient Greece, ancient China and modern social anthropology and philosophy of science to explore the problems of translation and mutual intelligibility. It develops the idea of semantic stretch to qualify the literal/metaphorical (...) dichotomy and the notion of the multidimensionality of reality to clarify aspects of the controversy between realism and relativism. (shrink)

BLWith new text and full apparatus criticusThe Eudemian Ethics was one of two ethical treatises which Aristotle wrote on the subject of ethica or `matters to do with character'. Although the two works cover much the same ground, the Nicomachean Ethics is better known; the poor manuscript tradition of the Eudemian Ethics has made correct translation and interpretation of the text extremely difficult. The subject of the work is the choice of a certain means of conduct, made by a `man (...) of practical wisdom', between two extremes of behaviour: asceticism and yielding to uncontrolled impulses. Aristotle also stresses the notion of moral intention and the importance of virtue of character. This new Oxford Classical Text of the Eudemian Ethics is the result of many years of work. After Sir David Ross's death, his original text was substantially reworked and revised by his friend and colleague R. R. Walzer, who was aided in the revision by his former pupil Mrs Jean Mingay, who continued his work after his death in 1974. Mrs Mingay was fortunate in being able to make use of previously unpublished contributions from D. J. Allan after his death in the late seventies, and more recently has been helped in her work by the suggestions of Professor D. A. Russell, David Robinson, and Christopher Rowe. (shrink)

This empirical study of Fortune 1000 firms assesses the degree to which those firms have adopted various practices associated with corporate ethics programs. The study examines the following aspects of formalized corporate ethics activity: ethics-oriented policy statements; formalization of management responsibilities for ethics; free-standing ethics offices; ethics and compliance telephone reporting/advice systems; top management and departmental involvement in ethics activities; usage of ethics training and other ethics awareness activities; investigatory functions; and evaluation of ethics program activities. Results show a (...) high degree of corporate adoption of ethics policies, but wide variability in the extent to which these policies are implemented by various supporting structures and managerial activities. In effect, the vast majority of firms have committed to the low cost, possibly symbolic side of ethics management (e.g., adoption of ethics codes and policies, etc.). But firms differ substantially in their efforts to see that those policies or codes actually are put into practice. (shrink)

Several times each month, usually on a Thursday morning, I join one or more of my physician colleagues on teaching rounds. Most weeks these are traditional rounds, where an attending physician leads a group of medical students, residents, and clinical fellows from bed to bed reviewing charts, examining patients, and planning daily procedures. As a medical ethicist, my role is to discuss some of the ethical issues that are embedded in these decisions about medical care and help students to hone (...) the skills required to manage these issues successfully in the context of ongoing care.Although the clinical setting varies, questions of patient management are always at the center of teaching rounds. Since my training is in philosophy, and not in medicine or nursing, there have been occasions when this focus on patient care has prompted me to reflect upon my role as a medical ethicist in these contexts. Lacking even the most basic medical training, and having been remarkably fortunate in having had limited personal experiences as a patient, what can I possibly contribute to the training of physicians?I suspect that at some time or another most teachers, but perhaps especially those trained in the humanities, have moments when they question the usefulness of their teaching. In my case, by introducing perspectives from the humanities on teaching rounds, my hope is to add some balance to the often narrow focus on the ordering of diagnostic tests, scheduling of procedures, obtaining of patient consent, and other practical matters. I often stress, for example, how the patients with whom students and residents interact are not mere patients, but persons with lives outside the hospital that can be made profoundly better or worse as a result of the brief time they are seen in the hospital. I draw attention to the …. (shrink)

BLWith new text and full apparatus criticus The Eudemian Ethics was one of two ethical treatises which Aristotle wrote on the subject of ethica or `matters to do with character'. Although the two works cover much the same ground, the Nicomachean Ethics is better known; the poor manuscript tradition of the Eudemian Ethics has made correct translation and interpretation of the text extremely difficult. The subject of the work is the choice of a certain means of conduct, made by a (...) `man of practical wisdom', between two extremes of behaviour: asceticism and yielding to uncontrolled impulses. Aristotle also stresses the notion of moral intention and the importance of virtue of character. This new Oxford Classical Text of the Eudemian Ethics is the result of many years of work. After Sir David Ross's death, his original text was substantially reworked and revised by his friend and colleague R. R. Walzer, who was aided in the revision by his former pupil Mrs Jean Mingay, who continued his work after his death in 1974. Mrs Mingay was fortunate in being able to make use of previously unpublished contributions from D. J. Allan after his death in the late seventies, and more recently has been helped in her work by the suggestions of Professor D. A. Russell, David Robinson, and Christopher Rowe. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:The Evolution of Pragmatism in India: Ambedkar, Dewey, and the Rhetoric of Reconstruction by Scott R. StroudAlbert R. SpencerBy Scott R. StroudThe Evolution of Pragmatism in India: Ambedkar, Dewey, and the Rhetoric of Reconstruction Chicago and London: The University of Chicago Press, 2023. 302 pp., incl. indexMore scholarly attention needs to be paid to the mutual influences between Asian and American thought, especially with regards to the development, (...) legacy, and future of pragmatism. Fortunately, there have been several notable attempts. Throughout his works, Richard Shusterman frequently incorporates the perspectives of various East Asian philosophies into his articulation of somaesthetics. Multiple scholars have explored John Dewey’s lectures in China and their political and educational impact, such as Jessica Ching-Sze Wang’s John Dewey in China or The Democracy of the Dead by Roger T. Ames and David L. Hall. Still others have highlighted the influence of Indian thought on pragmatism’s forerunners, such as American Philosophy Before Pragmatism (Goodman 2015), American Pragmatism: An Introduction (Spencer 2020), and The Ethics of Oneness (Engles 2021). Perhaps the most interesting inquiries into this influence can be found in a special volume of The Journal of Aesthetic Education (Vol. 43, No. 1) where multiple scholars discuss pragmatism’s connections and comparisons to The Bhagavad Gita, Confucianism, and Taoism. Among these scholars is Scott Stroud whose most recent publication The Evolution of Pragmatism in India (2023) represents the culmination of nearly two decades of research on the subject with special attention to the continuities between pragmatism and Indian thought. In it, he meticulously explores the influence of John Dewey on one of his students, Bhimrao Ambedkar (1891–1956), who was a transformative figure in the founding of the nascent Republic of India. The result is a work of scholarship that shows the global relevance of pragmatism in the 20th Century, [End Page 456] introduces the fascinating philosophy of Ambedkar to a non-Indian audience, and provides an entry for further scholarship on this profound thinker and activist.Bhimrao Ambedkar was a critical figure in the birth of modern India. Born an “untouchable” due to the rigid caste system, he tirelessly advocated for the right of Dalits (“crushed” or “untouchables”). By the mid-20th century, he had greatly influenced Indian politics, safeguarded the interests of the oppressed, and played a key role in drafting the Indian Constitution. Separate to his role as a statesman, Ambedkar promoted Buddhism in the 1950s as an escape from caste oppression, culminating in his publication, The Buddha and His Dhamma (1957). While his name is less familiar outside of India, he was voted the “Greatest Indian” in a 2012 poll due to his profound impact on the nation’s post-independence development. These accomplishments were supported by an extensive education, but unlike most subjects of the British Empire, Ambedkar also studied in the United States. Stroud initiates his study by focusing on this formative period, specifically his time at Columbia University and the influence of the philosopher and psychologist John Dewey. While their relationship has been acknowledged, Stroud is the first to explore this relationship in depth and he not only reconstructs the influence of Dewey on Ambedkar’s Navayana Pragmatism but illuminates the ways that Ambedkar integrated, modified, and even resisted Dewey’s pragmatism.Stroud masterfully builds his reconstruction of this synergy between Dewey’s pragmatism and Ambedkar’s philosophy not out of ephemeral conjecture or pithy textual evidence, but through painstaking, detailed, and exhaustive scholarship. He draws on comparative evidence in their major and minor works, their private correspondence, interviews of Ambedekar’s cohort at Columbia, Dewey’s voluminous lecture notes, and even the marginalia and notecards found between the pages of Ambedkar’s pragmatism bookshelf. Indeed, I often found myself pleasantly distracted as I imagined Stroud’s academic pilgrimage throughout India, Columbia University, and the Center for Dewey Studies to find every scrap of relevant information. In our age of instant information and digital archives, it is refreshing and inspiring to encounter a scholar still willing to trek across the globe for answers to his inquiries. Despite his passion to uncover the influence of Dewey on Ambedekar, Stroud never reduces the... (shrink)

All wars have causes; some have pretexts. When Polybios distinguishes between the cause, the pretext, and the beginning of war, his language sounds curiously modern. When he summarizes the causes of the Second Punic War the modern reader is not so satisfied. The war was due, in his opinion, to the indignation of Hamilcar Barca, who had to accept peace when he could have continued fighting in Sicily; to the anger of the Carthaginians, when they were forced to surrender Sardinia; (...) and to the good fortune which attended their armies in Spain. A more recent account differs from Polybios not only on matters of detail. ‘It is true that it was Hannibal's attack on Saguntum, undertaken in full knowledge of the almost inevitable consequences, that precipitated the war, but the historian must decide that, so far as attack and defence have a meaning in the clash between states, the balance of aggression must incline against Rome.’. (shrink)

Magnanimity is often regarded as the heroic virtue of glory-seeking warriors and honour-loving aristocrats. But in the Nicomachean Ethics Aristotle presents magnanimity as a civic rather than a heroic virtue. By attending to Aristotle's often overlooked accounts of his indifference to honour and his attitudes towards fortune and towards others, I aim to show that so far from seeking only glory or self-sufficiency, the magnanimous man realizes his true greatness and nobility in his beneficence towards his fellow citizens.

This article traces the fortunes of John Duns Scotus in histories of philosophy from Melanchthon’s student Caspar Peucer to the eminent medievalist Étienne Gilson. It identifies themes and historiographical methods common to sources from the late sixteenth century and follows their development to the present, with special emphasis given to the socalled historia philosophiae philosophica first advanced by Lutheran historians during the early Enlightenment.

This book consists of a collection of essays written between 1965 and 1981. Some have been published elsewhere; others appear here for the first time. Although dealing with different figures and different periods, they have a common theme: all are concerned with examining how the method of hy pothesis came to be the ruling orthodoxy in the philosophy of science and the quasi-official methodology of the scientific community. It might have been otherwise. Barely three centuries ago, hypothetico deduction was in (...) both disfavor and disarray. Numerous rival methods for scientific inquiry - including eliminative and enumerative induction, analogy and derivation from first principles - were widely touted. The method of hypothesis, known since antiquity, found few proponents between 1700 and 1850. During the last century, of course, that ordering has been inverted and - despite an almost universal acknowledgement of its weaknesses - the method of hypothesis (usually under such descriptions as 'hypothetico deduction' or 'conjectures and refutations') has become the orthodoxy of the 20th century. Behind the waxing and waning of the method of hypothesis, embedded within the vicissitudes of its fortunes, there is a fascinating story to be told. It is a story that forms an integral part of modern science and its philosophy. (shrink)

Mele's ultimate purpose in this book is to help readers think more clearly about free will. He identifies and makes vivid the most important conceptual obstacles to justified belief in the existence of free will and meets them head on. Mele clarifies the central issues in the philosophical debate about free will and moral responsibility, criticizes various influential contemporary theories about free will, and develops two overlapping conceptions of free will--one for readers who are convinced that free will is incompatible (...) with determinism (incompatibilists), and the other for readers who are convinced of the opposite (compatibilists). Luck poses problems for all believers in free will, and Mele offers novel solutions to those problems--one for incompatibilist believers in free will and the other for compatibilists. An early chapter of this empirically well-informed book clearly explains influential neuroscientific studies of free will and debunks some extravagant interpretations of the data. Other featured topics include abilities and alternative possibilities, control and decision-making, the bearing of manipulation on free will, and the development of human infants into free agents. Mele's theory offers an original perspective on an important problem and will garner the attention of anyone interested in the debate on free will. (shrink)

In our turbulent and fast-changing days, is there anyone who still cares about truth? If this were, fortunately, the case, what leeway would those tenacious people have at disposal in order to find...

This study identifies and describes the values espoused by the 62 companies that have consistently appeared on the “Fortune 100 Best Companies to Work For” list. We identify 24 separate values and offer an analysis of the keywords and phrases used to promote them. We confirm that these values fall within the categories of four well-accepted theoretical frameworks of corporate values and culture. We then provide evidence for three underlying dimensions transcending all four models. They are values that guide (...) relationships and self-regulation; values that describe desired outcomes and performance; and values that inform learning and change. Next, we present the results of a qualitative study describing how these companies put their values into practice. Finally, using publicly available information from the Great Place to Work® Institute, we show how the espoused values we identified relate to: what employees report about their experiences and company self-descriptions. Our findings highlight connections between leadership and values and they offer guidance to those seeking to understand keys to values-based cultures. (shrink)

Heidegger's book is both Kant's good fortune and ours; as a philosopher, Heidegger's treatment is guided by the thesis that ontology is founded on transcendental philosophy, and that it is prior to metaphysica specialis, i.e., cosmology, psychology, and theology. As a scholar, Heidegger finely dissects the Transcendental Analytic, arguing that man's finitude consists in the required cooperation of sensibility and understanding, both of which stem, as Kant intimated, from imagination; and time is of the essence of imagination. Heidegger's vigorous (...) defense of the Schematism is a superb example of imaginative philosophy and careful scholarship well blended. The translator lacks confidence in the English language, and often uses English merely as a clue to Heidegger's German. --R. C. N. (shrink)

Ordinary usage supports both a relatively strong belief requirement on intention and a tight conceptual connection between intention and intentional action. More specifically, it speaks in favor both of the view that "S intends to A" entails "S believes that he (probably) will A" and of the thesis that "S intentionally A-ed" entails "S intended to A." So, at least, proponents of these ideas often claim or assume, and with appreciable justification. The conjunction of these two ideas, however, has some (...) highly counterintuitive implications. This suggests that a certain skepticism about the coherence of ordinary usage of "intention" may be salutary. Fortunately, the skeptic need not abandon the quest for understanding. Much can be gleaned from a careful investigation of the functions attributed to intention in the literature. In this paper, I argue that the capacity of intention to do the work that the literature assigns it does not depend upon intentional A-ing's entailing intending to A, nor upon there being a strong belief constraint on intention, nor even a certain relatively weak belief constraint. I also develop an account of the features of intention in virtue of which it is capable of doing this work. This account provides the core of an adequate conception of intention. Toward the end of the paper, I briefly motivate acceptance of a modest belief requirement on non-functional grounds. (shrink)

While evidence exists suggesting that irresponsible corporate behaviour may lead to decreased shareholder wealth (Frooman 1997), one cannot help but question the generalizability of these results when companies such as Exxon, an organization well known for its environmental problems, remains at the top of the 2006 Fortune 500 list. In this paper we show with regards to news of irresponsible behaviour, the market punishes smaller, less capitalized firms but not necessarily the very large and highly capitalized companies.

Mele's ultimate purpose in this book is to help readers think more clearly about free will. He identifies and makes vivid the most important conceptual obstacles to justified belief in the existence of free will and meets them head on. Mele clarifies the central issues in the philosophical debate about free will and moral responsibility, criticizes various influential contemporary theories about free will, and develops two overlapping conceptions of free will--one for readers who are convinced that free will is incompatible (...) with determinism (incompatibilists), and the other for readers who are convinced of the opposite (compatibilists). Luck poses problems for all believers in free will, and Mele offers novel solutions to those problems--one for incompatibilist believers in free will and the other for compatibilists. An early chapter of this empirically well-informed book clearly explains influential neuroscientific studies of free will and debunks some extravagant interpretations of the data. Other featured topics include abilities and alternative possibilities, control and decision-making, the bearing of manipulation on free will, and the development of human infants into free agents. Mele's theory offers an original perspective on an important problem and will garner the attention of anyone interested in the debate on free will. (shrink)

ABSTRACTPeople often use metaphors to discuss their financial prospects – for example, finding a fortune or searching for wealth. The purpose of the present research was to utilize conceptual metap...

It is meet and right that pride and humility should be the two human characteristics on which University sermons have to be preached. Left to myself, although I might have picked on my modesty as something I should share with you, I should have given the preeminence to other among my sins than pride. My greed, my sloth, my avarice or, in this salacious age my lust, are subjects on which I could tell you much that might interest you. Pride (...) lacks immediate appeal. We are not sure what it is, or whether it is a bad thing, when we think of it in purely individual terms. But when we consider it collectively, we can see that it is, together with humility, something Oxford is peculiarly well qualified to preach on. We all of us are proud of our university. We were proud, and our schoolmasters were proud, when we first got our places here. We are, dons and undergraduates alike, proud of our colleges, each grateful that good fortune has brought him to the best college in Oxford, and anxious that everyone else should secretly acknowledge it to be the best. Our parents were proud when we took our degrees, and although we profess to be unconcerned with classes, we are deeply content to record our firsts when occasion requires us to do so, or have our contemporaries allude to them as opportunity offers. We are studious, as dons, not to pull rank, safe in the knowledge that others will do it for us, and that we shall receive the deference due to a fellow of an Oxford college. In an age that is egalitarian in theory but elitist at heart, Oxford men have benefited greatly, as other forms of social eminence have been eroded, leaving a clear field for our own claims to public esteem, which are, if not entirely unchallenged, still generally allowed. Oxford is, as we like to be told by outsiders, a centre of excellence, and a lot of the resplendence rubs off on us, not altogether undeservedly. It is, as we corporately admit on Commemoration Sunday, largely due to our having entered into other men's labours.. (shrink)

The 18th century philosopher and Anglican bishop, George Berkeley, is chiefly known to posterity for advocating the radical thesis that there is no unthinking stuff in the world. According to Berkeley, bar stools, kegs, mugs and the all paraphernalia of ordinary life (plus everything else) are merely ideas and have no existence outside the mind of those seated on the stools, tapping the kegs, and drinking from the mugs. What is less well-known is that Berkeley devoted much of his energy (...) in later life to promoting the use of a concoction he called tar-water for the treatment of a wide variety of health ailments. Fortunately, Berkeley thought that many of the same virtues were found in some beers. It may seem paradoxical that one and the same man could both claim that beer only exists as an idea in the minds of those consuming it and that it could cure all known afflictions. Berkeley's resolution of this paradox will be explored and it will be seen that it is possible to both appreciate and benefit from beer even if it is only an idea. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:69 WILLIAM ROBERTSON AND DAVID HUME: THREE LETTERS The relationship between David Hume and his fellow Scottish historian William Robertson has always seemed one-sided. Despite the existence of fifteen letters to Robertson in the standard volumes of Hume's correspondence,1 Hume scholars have long had reason to regret the lack of a single extant letter from Robertson to Hume. None are to be found, for example, where one would most (...) expect them to be — in the Royal Society of Edinburgh, alongside the letters to Hume from various other Moderate clergymen and literati in Robertson's circle, such as Hugh Blair and Adam Ferguson. Fortunately, however, two of Robertson's letters to Hume (numbered II and III below) have now turned up where one would not expect them to be — among Robertson's own correspondence in the Robertson2 Macdonald Papers, National Library of Scotland. They are not mere drafts, such as one is accustomed to find among an author's private papers; rather, they are autograph signed letters that appear to have actually been posted. How and when they found their way back to Robertson's personal papers, and what became of the rest of Robertson's letters to Hume, are questions open to speculation. For the moment we are grateful for the letters we now have, neither of which is known to have been published before in whole or in part. Nor has Hume been identified before as the recipient of either of these letters, though internal evidence makes it clear that he was. Both letters date from the late 1760s, when Hume was living in London and Robertson was at the peak of his multi-faceted career in Edinburgh as university principal, parish minister, ecclesiastical leader, and man of letters. The first of them, dated 27 March 1767, was sent to Hume in his capacity as under- 70 secretary of state in the Northern Department (an office he held from February 1767 to January 1768). It is plainly a reply to a letter of 19 March, in which Hume had discussed three topics to which Robertson was 5 responding: Robertson's efforts to secure a military chaplaincy for a certain Scottish minister (evidently named Brodie); Conway's role in the famous dispute between Hume and Rousseau; and the public response to Adam Ferguson's newly published Essay on the History of Civil Society. In addition Robertson addresses a matter that Hume had apparently broached with him at some earlier time: the attempt to find a suitable Scottish church to which Hume might obtain a crown presentation for his nephews' tutor, the Rev. Christopher Tait. The letter concludes on a note of admiration that is characteristic not only of Robertson but of most of Hume's other "Protestant Pastors" in Scotland. The second letter to Hume, dated 31 January 1769, is chiefly concerned with the forthcoming publication of Robertson's History of Charles V and the French translation of it by J.-B.-A. Suard — subjects that had been treated in two letters from Hume to 7 Robertson of autumn 1768. It also contains a strong recommendation for a bright young Scottish writer (in both the legal and literary senses of that term) who would one day become Robertson's most vitriolic critic: Gilbert Stuart. On the personal side, there is encouragement for the now unemployed Hume to return to Edinburgh, as he was then threatening to do, after his "great glut of society" at Paris and London, and there are allusions in the closing paragraph to Hume's part in introducing his friend to polite society when Robertson had visited London to arrange the publication of Charles V in the spring of 1768. 71 To these two letters from Robertson we have prefixed a third from earlier in the same decade, one Q not actually addressed to Hume but largely about him. Robertson wrote it to their common friend Gilbert Elliot (later Sir Gilbert Elliot) on 8 March 1762, two days before the Town Council elected Robertson principal of Edinburgh University. The first paragraph deals with the principalship and relates to Hume only indirectly, as we point out in a footnote. The second paragraph, however, contains interesting... (shrink)

Generally the theist's defense against the argument from evil invokes the libertarian ideal. But this route is not open to compatibilist Reformed theologians. They must show either that God's possibly creating humans with a more perfect nature is either an impossibility or that his doing so violates some fundamental principle of value. I argue that the compatibilist Reformed theologian is unsuccessful in both. Specifically, in the latter case, there is no ground for thinking that redemption and its associated evil (as (...) found in the concept of a fortunate fall) are superior to persistent innocence. (shrink)

Kolakowski describes his massive and comprehensive study of Marxism as a "handbook." Following a classic pattern, he divides his study into three volumes, "The Founders," "The Golden Age," and "The Breakdown." Kolakowski does not claim to present a non-controversial account of the history of Marxism, however, his aim is "to include the principal facts that are likely to be of use to anyone seeking an introduction to the subject". The main organizing principle is chronological, although Kolakowski frequently departs from strict (...) chronology in order to deal with thinkers who share affinities in their approach to Marxism or to present background information about the historical context and alternatives to Marxism. The first volume begins with a discussion of the origins of dialectic that reaches back to the pre-Socratics carrying us through the neo-Platonic tradition to Kant, Fichte, and Hegel. This is followed by an analysis of the views of the left Hegelians and a detailed exposition of Marx, from his early to his mature writings. The volume concludes with a discussion of Engels’s understanding of the dialectics of nature. Volume 2 begins with an analysis of Marxism and the Second International. There are separate chapters on Karl Kautsky, Rosa Luxemburg, Eduard Bernstein, Jean Jaurès, Paul Lafargue, Georges Sorel, Antonio Labriola, Ludwik Krzywicki, Kasimierz Kelles-Krauz, Stanislaw Brzozowski, and the Austro-Marxists. Kolakowski then treats in detail the origins of Russian Marxism culminating in a discussion of Leninism and its fortunes. The final volume follows the bleak story of Soviet Marxism, but also treats the alternatives to Soviet ideology with chapters on Antonio Gramsci, György Lukács, Karl Korsch, Lucien Goldmann, the Frankfurt School, Herbert Marcuse, and Ernst Bloch. There is a final chapter that surveys developments in Marxism since Stalin’s death. The main emphasis is on European Marxism although there is a brief discussion of the peasant Marxism of Mao-Tse-tung. The erudition, the mastery of detail, and the scope exhibited is remarkable. There is nothing comparable to this work in English. The style is so lucid and the translation so good that it is difficult to believe that the study was not originally written in English. Both the novice and the advanced scholar can learn from these volumes. But the study is not really an introduction. Kolakowski’s expositions, interpretations, and criticisms are at once highly sophisticated and highly controversial. It is a handbook that needs to be used with caution despite Kolakowski’s claim that he had done his best "not to merge comment with exposition, but to present my own views in separate, clearly defined sections". (shrink)

The Plasmodium falciparum genome‐sequencing project has provided malariologists with vast amounts of new information pertinent to a multitude of cellular processes that previously were only guessed about. In exploring this morass of predicted genes and proteins, there is now a danger of simply re‐inventing the cell. Fortunately, new global transcriptional analyses reassure malariologists that they are not dealing with just “any old cell.” The informative papers on the plasmodial transcriptome by Le Roch et al. (2003)1 and Bozdech et al. (2003)2 (...) discussed below forge a bridge between the genomics and proteomics of P. falciparum. They are likely to act as a fulcrum upon which much future research will turn: for example, the study of regulation and feed‐back loops. BioEssays 26:339–342, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:The Environmental Genome Project and BioethicsRichard R. Sharp (bio) and J. Carl Barrett (bio)Eight years ago, the Kennedy Institute of Ethics Journal published a brief selection by Eric Juengst (1991) entitled “The Human Genome Project and Bioethics.” That essay introduced and described the Ethical, Legal, and Social Implications (ELSI) Program at the National Center for Human Genome Research. 1 Since that time, the ELSI program has grown to become (...) one of the largest and most well regarded bioethics programs in the country, sponsoring the work of hundreds of researchers and coordinating bioethics activities both nationally and internationally (Marshall 1996; Meslin, Thomson, and Boyer 1997). In 1991, however, Juengst, the first director of the ELSI program, had no way of anticipating these developments. Juengst’s goal in his essay was simply to highlight some of the moral and social issues that were emerging as focal points for the ELSI program. Looking back, the issues he outlined may seem vague and overly broad. At the time, however, the essay served an important purpose, to identify areas requiring additional study and thereby to serve as a guide to others interested in joining in these discussions.In many ways, Juengst’s article serves as an inspiration to those of us working on a new bioethics project. The National Institute of Environmental Health Sciences (NIEHS) recently launched a multi-year project aimed at better understanding genetic influences on environmentally associated diseases (Albers 1997; Brown and Hartwell 1998; Cannon 1997; Kaiser 1997). This project, known as the Environmental Genome Project (EGP), plans to identify and study a number of common genetic variants that may play an important role in determining how individuals respond to environmental exposures. NIEHS hopes that the information learned through the EGP will be instrumental in developing more effective disease-prevention strategies and intervention programs. Following the precedent developed in connection with the Human Genome Project, NIEHS also plans to address the moral and social implications of the EGP. Efforts in this regard include sponsoring workshops and conferences to address such issues, as well as supporting research on the ethical, legal, and social implications of the EGP. Through this work, NIEHS hopes to anticipate potential problems before [End Page 175] they arise and to develop policies that maximize the benefits of the research while avoiding potential misuses of the information learned.In exploring the social implications of the EGP, we at NIEHS are very fortunate to be able to draw upon the work being done by the ELSI program at the National Human Genome Research Institute (NHGRI), as well as the ever-expanding bioethics literature that has been sparked by the ELSI program. Still, there is much to be done and this is an exciting time for those of us involved with the EGP. Many of the ethical, legal, and social implications of the project are only beginning to become clearer, and several of these issues appear quite different from the sorts of concerns that have previously been discussed in connection with other types of genetic research.This essay highlights some of the ethical, legal, and social implications that are emerging as important focal points for the Environmental Genome Project. Like Juengst’s 1991 paper, the goal of this article is to provide an overview of current areas of interest and to encourage others to join us in thinking about these difficult issues.The Environmental Genome ProjectIndividuals differ greatly in their responses to chemicals, drugs, radiation, smoking, alcohol, and other environmental exposures. These differential responses are the result of complex interactions between many factors, including an individual’s genetic make-up, age, sex, nutritional status, and overall health. The EGP aims to better understand the genetic basis of differential responses to environmental exposures. The vast majority of diseases, many forms of cancer, for example, are the consequence of both environmental and genetic contributions (Perera 1997). Hence, understanding the relationships between genetic variation and response to environmental exposure is important for understanding the causes of human disease and is crucial for the development of effective disease-prevention strategies.The EGP and projects like it represent a new stage of genomic research. It is expected that the Human Genome Project will complete... (shrink)

En el presente artículo se presenta, desde la filosofía, primeramente la tesis de L. Zea, según el cual la universidad del hombre americano, se halla en la aceptación de la diversidad concreta de las pluriformes maneras de ser de los americanos. Europa recién ahora se pone filosóficamente el problema de la pluralidad cultural. Se analiza luego la forma de considerar el gobierno y las leyes tanto de los americanos sajones como de los americanos latinos, cuando construyen sus propias formas de (...) ser. Se considera el intento y el fracaso al querer éstos imitar a aquéllos. Trata, además, la hipótesis de L. Zea según el cual la identidad de los pueblos latinoamericanos está en no tener ninguna que lo marque como pueblo y hombre común a toda América Latina, salvo ciertos rasgos de conducta común, derivados del talante conquistador español. Ortega y Gasset prolonga este análisis y lo centra en las influencias de la inmigración en Argentina, de lo que -entre otras causas- surge una explicación para ciertas conductas que dan forma a la identidad de los argentinos. Algo no ha cambiado en el modo de ser argentino: éste no se dedica primeramente a vivir la vida, sino a hacer fortuna y defenderse. Se identifica por lo que posee o desea poseer.This article presents, from a philosophical stand, firstly Leopoldo Zea's thesis according to which the American man's universality resides in his acceptance of the concrete diversity of the various ways of being American. Only now Europe is starting to consider philosophically the problem of cultural pluralism. Secondly, we analyze the way the Saxon Americans and the Latin Americans consider government and laws during their respective processes of becoming their own selves. We examine the intent and subsequent failure of the latter at trying to imitate the former; also, Zea's thesis according to which the identity of Latin American peoples lies precisely in not having a unique identity that define them as a man and people common to all Latin America, except for some behavioral traits deriving from the Spanish conqueror temper. Ortega y Gasset extends this analysis focusing on Argentina's immigration and concluding that this partially accounts for the Argentinean behavior and identity, their priority being to make a fortune and to defend themselves. Their identity rises from what they have or what they want to have. (shrink)